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Belief in the target and the molecule

DUBLIN – H. Lundbeck A/S is acquiring Prexton Therapeutics Ltd. in a deal that gives it ownership of foliglurax (PXT-002331), a first-in-class metabotropic glutamate receptor 4 (mGluR4) agonist currently undergoing a phase II trial as adjunct therapy in Parkinson's disease.

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GWAS in Chinese population implicates immune system in Alzheimer's disease

A study has identified common genetic variants in the Chinese population contributing to the risk of developing Alzheimer's disease (AD) that possibly exert functional effects through the immune system, which could have important implications for AD management.

The search continues for promising biomarkers and effective disease-modifying therapies for AD. The current drug development approaches mainly target the disease's hallmark pathology of amyloid-beta (Abeta) protein accumulation in the brain leading to Abeta plaque deposition.



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